Literature summary for 1.8.1.9 extracted from

Yoo, M.H.; Xu, X.M.; Carlson, B.A.; Patterson, A.D.; Gladyshev, V.N.; Hatfield, D.L.
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication (2007), PLoS ONE, 2, e1112.

Search for more literature for 1.8.1.9

Application

Application	Comment	Organism
medicine	TR1 acts largely as a pro-cancer protein and it is a primary target in cancer therapy	Mus musculus
medicine	TR1 acts largely as a pro-cancer protein and it is a primary target in cancer therapy	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
selenium	selenoprotein	Mus musculus
selenium	selenoprotein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16881	-	-
Mus musculus	Q9JMH6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	human lung non-small cell carcinoma	Homo sapiens	-
ACHN cell	human kidney renal cell carcinoma	Homo sapiens	-
HCT-116 cell	human colon cell adenocarcinoma	Homo sapiens	-
LLC1 cell	-	Mus musculus	-
NIH-3T3 cell	TR1 is uniquely overexpressed in cancer cells and its knockdown in a mouse cancer cell line driven by oncogenic k-ras results in orphological changes characteristic of parental (normal) cells, without significant effect on cell growth under normal growth conditions. When grown in serum-deficient medium, TR1 deficient cancer cells lose self-sufficiency of growth, manifest a defective progression in their S phase and a decreased expression of DNA polymerase alpha	Mus musculus	-
SNB-19 cell	human cell glioblastoma	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
thioredoxin reductase 1	-	Mus musculus
thioredoxin reductase 1	-	Homo sapiens
TR1	-	Mus musculus
TR1	-	Homo sapiens

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Release 2023.1 (January 2023)