Application | Comment | Organism |
---|---|---|
medicine | TR1 acts largely as a pro-cancer protein and it is a primary target in cancer therapy | Mus musculus |
medicine | TR1 acts largely as a pro-cancer protein and it is a primary target in cancer therapy | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | selenoprotein | Mus musculus | |
selenium | selenoprotein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16881 | - |
- |
Mus musculus | Q9JMH6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | human lung non-small cell carcinoma | Homo sapiens | - |
ACHN cell | human kidney renal cell carcinoma | Homo sapiens | - |
HCT-116 cell | human colon cell adenocarcinoma | Homo sapiens | - |
LLC1 cell | - |
Mus musculus | - |
NIH-3T3 cell | TR1 is uniquely overexpressed in cancer cells and its knockdown in a mouse cancer cell line driven by oncogenic k-ras results in orphological changes characteristic of parental (normal) cells, without significant effect on cell growth under normal growth conditions. When grown in serum-deficient medium, TR1 deficient cancer cells lose self-sufficiency of growth, manifest a defective progression in their S phase and a decreased expression of DNA polymerase alpha | Mus musculus | - |
SNB-19 cell | human cell glioblastoma | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase 1 | - |
Mus musculus |
thioredoxin reductase 1 | - |
Homo sapiens |
TR1 | - |
Mus musculus |
TR1 | - |
Homo sapiens |