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Literature summary for 1.8.1.9 extracted from

  • Arias, D.G.; Carranza, P.G.; Lujan, H.D.; Iglesias, A.A.; Guerrero, S.A.
    Immunolocalization and enzymatic functional characterization of the thioredoxin system in Entamoeba histolytica (2008), Free Radic. Biol. Med., 45, 32-39.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0028
-
thioredoxin disulfide 8 pH 7, 30°C Entamoeba histolytica
0.0036
-
thioredoxin disulfide 41 pH 7, 30°C Entamoeba histolytica

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Entamoeba histolytica 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Entamoeba histolytica the tandem system involving thioredoxin reductase and thioredoxin proves to be operative for reducing low molecular weight disulfides, including putative physiological substrates as cystine and oxidized trypanothione thioredoxin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Entamoeba histolytica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin disulfide + NADPH + H+ the tandem system involving thioredoxin reductase and thioredoxin proves to be operative for reducing low molecular weight disulfides, including putative physiological substrates as cystine and oxidized trypanothione Entamoeba histolytica thioredoxin + NADP+
-
?
thioredoxin disulfide 41 + NADPH + H+
-
Entamoeba histolytica thioredoxin 41 + NADP+
-
?
thioredoxin disulfide 8 + NADPH + H+
-
Entamoeba histolytica thioredoxin 8 + NADP+
-
?

Synonyms

Synonyms Comment Organism
EhTRXR
-
Entamoeba histolytica

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.43
-
thioredoxin disulfide 8 pH 7, 30°C Entamoeba histolytica
2.2
-
thioredoxin disulfide 41 pH 7, 30°C Entamoeba histolytica

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Entamoeba histolytica