Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.9 extracted from

  • Johansson, L.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.; Arner, E.S.
    Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme (2006), Free Radic. Biol. Med., 41, 649-656.
    View publication on PubMed
Search for more literature for 1.8.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
C458S inactive mutant of SCCS Rattus norvegicus
C458S/C475T inactive mutant of SCCS Rattus norvegicus
C475T inactive mutant of SCCS Rattus norvegicus
SCCS mutant with flanking serine residues introduced into the C-terminal tetrapeptide of the wild type enzyme, less than 0.5% activity of the wild type enzyme Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O89049
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
-
 Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
 ?
selenite + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
thioredoxin + NADP+
-
 Rattus norvegicus thioredoxin disulfide + NADPH
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Rattus norvegicus
TrxR
-
 Rattus norvegicus