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Literature summary for 1.8.1.9 extracted from

  • Cassidy, P.B.; Edes, K.; Nelson, C.C.; Parsawar, K.; Fitzpatrick, F.A.; Moos, P.J.
    Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles (2006), Carcinogenesis, 27, 2538-2549.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
15-deoxy-D-12,14-PGJ2 0.06 mM, IC50: 0.00036 mM Rattus norvegicus
3,4-estronequinone 0.032 mM, IC50: 0.02 mM Rattus norvegicus
4-hydroxynonenal 0.06 mM, IC50: 0.012 mM Rattus norvegicus
leukotriene A4 methyl ester 0.06 mM, IC50: 0.513 mM Rattus norvegicus
Prostaglandin A2 0.06 mM, IC50: 0.068 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DE52 column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin + NADP+
-
Rattus norvegicus thioredoxin disulfide + NADPH
-
?

Subunits

Subunits Comment Organism
homodimer
-
Rattus norvegicus

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
Rattus norvegicus
TrxR
-
Rattus norvegicus
TrxR1
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000024
-
15-deoxy-D-12,14-PGJ2
-
Rattus norvegicus
0.0008
-
4-hydroxynonenal
-
Rattus norvegicus
0.001
-
3,4-estronequinone
-
Rattus norvegicus
0.0045
-
Prostaglandin A2
-
Rattus norvegicus
0.033
-
leukotriene A4 methyl ester
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00036
-
0.06 mM, IC50: 0.00036 mM Rattus norvegicus 15-deoxy-D-12,14-PGJ2
0.012
-
0.06 mM, IC50: 0.012 mM Rattus norvegicus 4-hydroxynonenal
0.02
-
0.032 mM, IC50: 0.02 mM Rattus norvegicus 3,4-estronequinone
0.068
-
0.06 mM, IC50: 0.068 mM Rattus norvegicus Prostaglandin A2
0.513
-
0.06 mM, IC50: 0.513 mM Rattus norvegicus leukotriene A4 methyl ester