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Literature summary for 1.8.1.9 extracted from
- Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci) (2004), Mol. Biochem. Parasitol., 133, 61-69.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| auranofin | - |
Taenia crassiceps |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
NADPH | - |
Taenia crassiceps | |
| 0.015 | - |
GSSG | - |
Taenia crassiceps | |
| 0.017 | - |
thioredoxin disulfide | - |
Taenia crassiceps | |
| 0.049 | - |
5,5'-dithiobis(2-nitrobenzoic acid) | - |
Taenia crassiceps | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Taenia crassiceps | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | contains an essential selenocysteine residue | Taenia crassiceps | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
2 * 66000, SDS-PAGE | Taenia crassiceps |
| 136000 | - |
gel filtration | Taenia crassiceps |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Taenia crassiceps | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Taenia crassiceps |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 10.3 | - |
GSSG + NADPH | Taenia crassiceps |
| 17.5 | - |
thioredoxin disulfide + NADPH | Taenia crassiceps |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | - |
Taenia crassiceps | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| GSSG + NADPH | - |
Taenia crassiceps | GSH + NADP+ | - |
? | |
| thioredoxin disulfide + NADPH | - |
Taenia crassiceps | thioredoxin + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 66000, SDS-PAGE | Taenia crassiceps |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| multifunctional thioredoxin-glutathione reductase | - |
Taenia crassiceps |
| TGR | - |
Taenia crassiceps |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.1 | - |
GSSG | - |
Taenia crassiceps | |
| 19.2 | - |
thioredoxin disulfide | - |
Taenia crassiceps | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | contains 1.2 mol per mol of enzyme subunit | Taenia crassiceps | |
| NADPH | - |
Taenia crassiceps | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Taenia crassiceps | - |
- |
5.2 |
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