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Literature summary for 1.8.1.9 extracted from
- Thioredoxin reductase from the malaria mosquito Anopheles gambiae (2003), Eur. J. Biochem., 270, 4272-4281.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Anopheles gambiae |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0085 | - |
thioredoxin | thioredoxin-1 from Anopheles gambiae, pH 7.4 | Anopheles gambiae |  |
| 0.009 | - |
thioredoxin | thioredoxin-2 from Drosophila melanogaster, pH 7.4 | Anopheles gambiae | |
| 0.033 | - |
thioredoxin | thioredoxin-1 from Plasmodium falciparum, pH 7.4 | Anopheles gambiae | |
| 0.7 | - |
5,5'-dithiobis(2-nitrobenzoic acid) | pH 7.4 | Anopheles gambiae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not a selenoenzyme, but instead contains a highly unusual redox-active Cys-Cys sequence | Anopheles gambiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anopheles gambiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Anopheles gambiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | - |
Anopheles gambiae | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| thioredoxin disulfide + NADPH | thioredoxin-1 from Anopheles gambiae or Plasmodium falciparum, thioredoxin-2 from Drosophila melanogaster | Anopheles gambiae | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase-1 | - |
Anopheles gambiae |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.5 | - |
5,5'-dithiobis(2-nitrobenzoic acid) | pH 7.4 | Anopheles gambiae | |
| 14.3 | - |
thioredoxin | thioredoxin-2 from Drosophila melanogaster, pH 7.4 | Anopheles gambiae | |
| 15.4 | - |
thioredoxin | thioredoxin-1 from Anopheles gambiae, pH 7.4 | Anopheles gambiae | |
| 15.7 | - |
thioredoxin | thioredoxin-1 from Plasmodium falciparum, pH 7.4 | Anopheles gambiae | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | contains FAD | Anopheles gambiae | |
| NADPH | - |
Anopheles gambiae | |
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Release 2023.1 (January 2023)
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