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Literature summary for 1.8.1.9 extracted from
- Thioredoxin and thioredoxin reductase in pancreatic islets may participate in diabetogenic free-radical production (1982), Biochem. Biophys. Res. Commun., 107, 1412-1418.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin + NADP+ | Escherichia coli | - |
thioredoxin disulfide + NADPH | - |
? |  |
| thioredoxin + NADP+ | Mus musculus | reduction of free radicals at the surface of the epidermis, enzyme may play a role in physiology of pancreatic beta-cells | thioredoxin disulfide + NADPH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic islet | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Mus musculus |
| additional information | - |
- |
Escherichia coli |
| additional information | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Mus musculus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Escherichia coli | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | i.e. DTNB | Bos taurus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | requires thioredoxin for reduction of DTNB | Mus musculus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | requires thioredoxin for reduction of DTNB | Escherichia coli | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
| alloxan + NADPH | - |
Mus musculus | ? | - |
? | |
| alloxan + NADPH | - |
Escherichia coli | ? | - |
? | |
| alloxan + NADPH | - |
Bos taurus | ? | - |
? | |
| thioredoxin + NADP+ | - |
Mus musculus | thioredoxin disulfide + NADPH | - |
ir | |
| thioredoxin + NADP+ | - |
Escherichia coli | thioredoxin disulfide + NADPH | - |
? | |
| thioredoxin + NADP+ | - |
Escherichia coli | thioredoxin disulfide + NADPH | - |
ir | |
| thioredoxin + NADP+ | - |
Bos taurus | thioredoxin disulfide + NADPH | - |
ir | |
| thioredoxin + NADP+ | reduction of free radicals at the surface of the epidermis, enzyme may play a role in physiology of pancreatic beta-cells | Mus musculus | thioredoxin disulfide + NADPH | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
| NADPH | - |
Escherichia coli | |
| NADPH | - |
Bos taurus | |
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