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Literature summary for 1.8.1.8 extracted from

  • Jeong, W.; Lee, D.Y.; Park, S.J.; Rhee, S.G.
    ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress (2008), J. Biol. Chem., 283, 25557-25566.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.8

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli. Expression of ERp16 in HeLa cells inhibits the induction of apoptosis by agents that elicit ER stress, including brefeldin A, tunicamycin, and dithiothreitol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum ERp16 mediates disulfide bond formation in the endoplasmic reticulum and plays an important role in cellular defense against prolonged ER stress Homo sapiens 5783
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
16400
-
 2 * 16400, SDS-PAGE Homo sapiens
34900
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin disulfide + NADPH
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 16400, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ERp16
-
 Homo sapiens
thiol-disulfide oxidoreductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens