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Literature summary for 1.8.1.7 extracted from

  • Gonul Baltaci, N.; Guler, C.; Ceylan, H.; Kalin, S.N.; Adem, S.; Kocpinar, E.F.; Erdogan, O.; Budak, H.
    In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen (2018), J. Biochem. Mol. Toxicol., 2018, e22229 .
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Fe3+ stimulates, AC50 value: 0.327 mM. Enzymatic activity in the presence of nontoxic iron (0.87 and 3 ppm) is activated, no changes are seen in the presence of toxic iron concentrations (30 and 300 ppm) Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
126000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus F1LRE1
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
51.25
-
pH 7.6, and temperature not specified in the publication Rattus norvegicus

Subunits

Subunits Comment Organism
dimer 2 * 62000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
glutathione reductase
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus gene expressions is significantly repressed in the presence of nontoxic (0.87 and 3 ppm) and toxic iron concentrations (30 and 300 ppm) down