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Literature summary for 1.8.1.7 extracted from

  • Garcia-Leiro, A.; Cerdan, M.E.; Gonzalez-Siso, M.I.
    A functional analysis of Kluyveromyces lactis glutathione reductase (2010), Yeast, 27, 431-441.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Kluyveromyces lactis 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH + H+ Kluyveromyces lactis
-
glutathione + NADP+
-
?
glutathione disulfide + NADPH + H+ Kluyveromyces lactis NRRL-Y1140
-
glutathione + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Kluyveromyces lactis
-
i.e. CBS2359
-
Kluyveromyces lactis NRRL-Y1140
-
i.e. CBS2359
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Kluyveromyces lactis glutathione + NADP+
-
?
glutathione disulfide + NADPH + H+
-
Kluyveromyces lactis NRRL-Y1140 glutathione + NADP+
-
?

Synonyms

Synonyms Comment Organism
GLR
-
Kluyveromyces lactis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Kluyveromyces lactis

General Information

General Information Comment Organism
malfunction cells lacking the enzyme show decreased resistance to oxidative stress (H2O2) and 2fold higher levels of reactive oxygen species and catalase activity than the wild type strain Kluyveromyces lactis
metabolism the enzyme is involved in glucose metabolism Kluyveromyces lactis