Activating Compound | Comment | Organism | Structure |
---|---|---|---|
amikacin | - |
Homo sapiens | |
amoxicillin | - |
Homo sapiens | |
clindamycin | - |
Homo sapiens | |
Lincomycin | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceftazidime | competitive inhibition | Homo sapiens | |
ceftriaxone | competitive inhibition | Homo sapiens | |
cefuroxime | competitive inhibition | Homo sapiens | |
chloramphenicol | competitive inhibition | Homo sapiens | |
Imipenem | competitive inhibition | Homo sapiens | |
ornidazole | competitive inhibition | Homo sapiens | |
rifamycin | competitive inhibition | Homo sapiens | |
sulfanylacetamide | competitive inhibition | Homo sapiens | |
Vancomycin | noncompetitive inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B column chromatography and Sephadex G-200 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.01 | - |
hemolysate, at 25°C, pH 8.0 | Homo sapiens |
28 | - |
after 2800fold purification, at 25°C, pH 8.0 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EC 1.6.4.2 | formerly | Homo sapiens |
glutathione reductase | - |
Homo sapiens |
NADPH:oxidized glutathione oxidoreductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
Imipenem | at 25°C, pH 8.0 | Homo sapiens | |
0.085 | - |
sulfanylacetamide | at 25°C, pH 8.0 | Homo sapiens | |
0.275 | - |
rifamycin | at 25°C, pH 8.0 | Homo sapiens | |
3.59 | - |
ceftazidime | at 25°C, pH 8.0 | Homo sapiens | |
3.71 | - |
ceftriaxone | at 25°C, pH 8.0 | Homo sapiens | |
3.85 | - |
chloramphenicol | at 25°C, pH 8.0 | Homo sapiens | |
15.11 | - |
Vancomycin | at 25°C, pH 8.0 | Homo sapiens | |
23.5 | - |
cefuroxime | at 25°C, pH 8.0 | Homo sapiens | |
28.49 | - |
ornidazole | at 25°C, pH 8.0 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03 | - |
at 25°C, pH 8.0 | Homo sapiens | Imipenem | |
0.146 | - |
at 25°C, pH 8.0 | Homo sapiens | rifamycin | |
0.59 | - |
at 25°C, pH 8.0 | Homo sapiens | sulfanylacetamide | |
2.36 | - |
at 25°C, pH 8.0 | Homo sapiens | chloramphenicol | |
2.476 | - |
at 25°C, pH 8.0 | Homo sapiens | ceftazidime | |
2.88 | - |
at 25°C, pH 8.0 | Homo sapiens | ceftriaxone | |
4.83 | - |
at 25°C, pH 8.0 | Homo sapiens | Vancomycin | |
15.43 | - |
at 25°C, pH 8.0 | Homo sapiens | cefuroxime | |
19.63 | - |
at 25°C, pH 8.0 | Homo sapiens | ornidazole |