Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ampicillin | leads to slight activation in vivo | Rattus norvegicus | |
gentamycin sulfate | leads to slight activation in vivo | Rattus norvegicus | |
penicillin G | leads to slight activation in vivo | Rattus norvegicus | |
streptomycin sulfate | leads to slight activation in vivo | Rattus norvegicus | |
teicoplanin | leads to slight activation in vivo | Rattus norvegicus | |
Thiamphenicol | leads to slight activation in vivo | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cefodizime | competitive inhibition, in vitro | Homo sapiens | |
cefodizime | competitive, 21% inhibition in vivo, effect decreases with time | Rattus norvegicus | |
cefotaxime | noncompetitive inhibition, in vitro | Homo sapiens | |
cefotaxime | noncompetitive, 46% inhibition in vivo, effect decreases with time | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH | Homo sapiens | - |
glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | Rattus norvegicus | - |
glutathione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
5342fold to homogeneity from erythrocytes by hemolysis, ammonium sulfate fractionation, affinity chromatography, and gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
erythrocyte | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
50.75 | - |
purified erythrocyte enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
glutathione disulfide + NADPH | - |
Rattus norvegicus | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione reductase | - |
Homo sapiens |
glutathione reductase | - |
Rattus norvegicus |
GR | - |
Homo sapiens |
GR | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.745 | - |
cefodizime | pH 8.0, 25°C | Homo sapiens | |
6.51 | - |
cefotaxime | pH 8.0, 25°C | Homo sapiens |