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Literature summary for 1.8.1.4 extracted from

  • Tyx, R.E.; Roche-Hakansson, H.; Hakansson, A.P.
    Role of dihydrolipoamide dehydrogenase in regulation of raffinose transport in Streptococcus pneumoniae (2011), J. Bacteriol., 193, 3512-3524.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
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General Information

General Information Comment Organism
physiological function like the raffinose ATP-binding protein RafK, the presence of the enzyme also activates the expression of raf operon genes. Enzyme-negative pneumococci show a significantly decreased expression of aga and rafEFG, but dihydrolipoamide dehydrogenase does not regulate rafK or the putative regulatory genes rafR and rafS. Dihydrolipoamide dehydrogenase also binds directly to RafK both in vitro and in vivo, indicating the possibility that dihydrolipoamide dehydrogenase regulates raffinose transport by a direct interaction with the regulatory domain of the transporter Streptococcus pneumoniae