Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dose dependently enhances the lipoamide dehydrogenase activity | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | lipoamide dehydrogenase activity and metallothionein levels may be critical for dopaminergic neuronal survival in Parkinson's disease. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine can affect the lipoamide dehydrogenase activity and metallothionein content to exert its neurotoxicity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | at higher concentrations (2 mM) significantly inhibits the lipoamide dehydrogenase activity | Mus musculus | |
1-methyl-4-phenylpyridinium | at lower concentrations (1 mM) as compared to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine significantly inhibits the lipoamide dehydrogenase activity | Mus musculus | |
Fe2+ | at high concentrations has significant inhibitory effect on the lipoamide dehydrogenase activity | Mus musculus | |
additional information | calcium and copper do not affect the enzyme activity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57/Bl-6 mice | - |
Mus musculus C57/Bl-6 | - |
C57/Bl-6 mice | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
coenzyme Q-10 + NADPH | - |
Mus musculus | ubiquinol + NADP+ | - |
? | |
coenzyme Q-10 + NADPH | - |
Mus musculus C57/Bl-6 | ubiquinol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoamide dehydrogenase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus |