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Literature summary for 1.8.1.4 extracted from

  • Luis, P.B.; Ruiter, J.P.; Aires, C.C.; Soveral, G.; de Almeida, I.T.; Duran, M.; Wanders, R.J.; Silva, M.F.
    Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007), Biochim. Biophys. Acta, 1767, 1126-1133.
    View publication on PubMed
Search for more literature for 1.8.1.4

Application

Application Comment Organism
degradation decreased activity of DLDH induced by valproic acid metabolites may, at least in part, account for the impaired rate of oxygen consumption and ATP synthesis in mitochondria if 2-oxoglutarate or glutamate are used as respiratory substrates, thus limiting the flux of these substrates through the citric acid cycle Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
valproyl-CoA competitive inhibitor, 0.5-1.0 mM inhibit DLDH activity Rattus norvegicus
valproyl-dephosphoCoA uncompetitive inhibitor, 0.5-1.0 mM inhibit DLDH activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrolipoamide + NAD+
-
 Rattus norvegicus lipoamide + NADH
-
 ?

Synonyms

Synonyms Comment Organism
dihydrolipoamide dehydrogenase
-
 Rattus norvegicus
DLDH
-
 Rattus norvegicus
E3
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.43
-
 valproyl-CoA
-
 Rattus norvegicus
1.6
-
 valproyl-dephosphoCoA
-
 Rattus norvegicus