Crystallization (Comment) | Organism |
---|---|
crystal structure of thr enzyme (LiTR) at 3.6 A resolution in its reduced state (complex with trypanothione) and oxidized state | Leishmania infantum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(1-(benzo(b)thien-2-yl)cyclohexyl)piperidine | - |
Leishmania infantum | |
5-(5-(1-(pyrrolidin-1-yl)cyclohexyl)-1,3-thiazol-2-yl)-1H-indole | competitive inhibition | Leishmania infantum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | Leishmania infantum | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania infantum | A4HSF7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Leishmania infantum | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LiTR | - |
Leishmania infantum |