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Literature summary for 1.8.1.12 extracted from

  • Saccoliti, F.; Angiulli, G.; Pupo, G.; Pescatori, L.; Madia, V.N.; Messore, A.; Colotti, G.; Fiorillo, A.; Scipione, L.; Gramiccia, M.; Di Muccio, T.; Di Santo, R.; Costi, R.; Ilari, A.
    Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives (2017), J. Enzyme Inhib. Med. Chem., 32, 304-310 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.12

Cloned(Commentary)

Cloned (Comment) Organism
-
 Leishmania infantum

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with inhibitor 6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine. The inhibitor binds to the catalytic site and interacts with residues Glu466', Cys57 and Cys52 Leishmania infantum

Inhibitors

Inhibitors Comment Organism Structure
6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine i.e. RD 777. IC50 value 0.029 microM for promastigote assay. Competitive with respect to substrate trypanothione disulfide Leishmania infantum

Organism

Organism UniProt Comment Textmining
Leishmania infantum A4HSF7
-
-

Synonyms

Synonyms Comment Organism
TryR
-
 Leishmania infantum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
 6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine pH not specified in the publication, temperature not specified in the publication Leishmania infantum