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Literature summary for 1.8.1.12 extracted from

  • Lazarin-Bidoia, D.; Desoti, V.C.; Ueda-Nakamura, T.; Dias Filho, B.P.; Nakamura, C.V.; Silva, S.O.
    Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of involvement of reactive oxygen species and mitochondria owing to a reduction in trypanothione reductase activity (2013), Free Radic. Biol. Med., 60, 17-28.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
eupomatenoid-5 eupomatenoid-5 decreases enzyme activity, leading to a relative increase in reactive oxygen species that triggers mitochondrial depolarization followed by an absolute increase in mitochondrial reactive oxygen and nitrogen species production through the electron transport chain. This increase in reactive oxygen and nitro-gen species induces oxidative damage, leading to parasite death Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trypanothione disulfide + NADPH + H+ Trypanosoma cruzi
-
trypanothione + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
Trypanosoma cruzi
-
epimastigote
-
Trypanosoma cruzi
-
trypomastigote
-
Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH + H+
-
Trypanosoma cruzi trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
trypanothione reductase
-
Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Trypanosoma cruzi