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Literature summary for 1.8.1.12 extracted from
- Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target (2004), J. Enzyme Inhib. Med. Chem., 19, 57-63.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme is a therapeutic target | Leishmania amazonensis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Leishmania amazonensis | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Leishmania amazonensis | enzyme is associated with infective capacity of the parasite | ? | - |
? |  |
| trypanothione disulfide + NADPH | Leishmania amazonensis | - |
trypanothione + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania amazonensis | - |
isolated from infected mice | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, cell fractionation | Leishmania amazonensis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amastigote | axenic, high expression level | Leishmania amazonensis | - |
| additional information | parasites are cultured in macrophage cell line J774-G8 | Leishmania amazonensis | - |
| promastigote | infective metacyclic: high expression level, low activity and expression in non-infective promastigotes | Leishmania amazonensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme is associated with infective capacity of the parasite | Leishmania amazonensis | ? | - |
? | |
| trypanothione disulfide + NADPH | - |
Leishmania amazonensis | trypanothione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TR | - |
Leishmania amazonensis |
| trypanothione reductase | - |
Leishmania amazonensis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Leishmania amazonensis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Leishmania amazonensis | |
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Release 2023.1 (January 2023)
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