Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.12 extracted from

  • Fournet, A.; Inchausti, A.; Yaluff, G.; Royas De Arias, A.; Guinaudeau, H.; Bruneton, J.; Breidenbach, M.A.; Karplus, P.A.; Faerman, C.H.
    Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase (1998), J. Enzyme Inhib., 13, 1-9.
    View publication on PubMed

Application

Application Comment Organism
medicine target enzyme for chemotherapy against Chagas' disease Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
bisbenzylisoquinoline alkaloids e.g. cepharanthine, (-)curine, daphnoline, antioquine, limacine, cycleanine Trypanosoma cruzi
cepharanthine
-
Trypanosoma cruzi
cycleanine
-
Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
trypanothione disulfide with cepharanthine Trypanosoma cruzi
0.099
-
trypanothione disulfide with cycleanine Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Trypanosoma cruzi trypanothione + NADP+
-
?

Cofactor

Cofactor Comment Organism Structure
FAD
-
Trypanosoma cruzi
NADPH
-
Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0076
-
cepharanthine
-
Trypanosoma cruzi
0.194
-
cycleanine
-
Trypanosoma cruzi