Any feedback?
Literature summary for 1.8.1.12 extracted from
- Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus (1998), Mol. Microbiol., 29, 653-660.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activity is dependent on a redox-active cysteine at the active centre | Leishmania donovani |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| replacement clones of tyrA, cloning of replacement vector, several genotypes | Leishmania donovani |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
several replacement clones | Leishmania donovani |
| 0.362 | - |
- |
Leishmania donovani |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trypanothione disulfide + NADPH | - |
Leishmania donovani | trypanothione + NADP+ | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TR | - |
Leishmania donovani |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Leishmania donovani | |
| NADPH | - |
Leishmania donovani | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
