BRENDA - Enzyme Database show
show all sequences of 1.7.2.3

High substrate specificity and induction characteristics of trimethylamine N-oxide reductase of Escherichia coli

Iobbi-Nivol, C.; Pommier, J.; Simala-Grant, J.; Mejean, V.; Giordano, G.; Biochim. Biophys. Acta 1294, 77-82 (1996)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.02
-
4-methylmorpholine N-oxide
-
Escherichia coli
0.07
-
Trimethylamine N-oxide
-
Escherichia coli
0.26
-
alpha-picoline N-oxide
-
Escherichia coli
0.32
-
gamma-picoline N-oxide
-
Escherichia coli
0.75
-
3-hydroxypyridine N-oxide
-
Escherichia coli
1.14
-
N,N-dimethylhexylamine N-oxide
-
Escherichia coli
1.25
-
N,N-dimethyldodecylamine N-oxide
-
Escherichia coli
1.86
-
Pyridine N-oxide
-
Escherichia coli
2.01
-
2-chloropyridine N-oxide
-
Escherichia coli
2.15
-
4-chloropyridine N-oxide
-
Escherichia coli
4.74
-
N-cyclohexyldimethylamine N-oxide
-
Escherichia coli
5.43
-
3-picoline N-oxide
-
Escherichia coli
7.39
-
hydroxylamine N-oxide
-
Escherichia coli
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
inducible enzyme
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
33
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM and a concentration 20 mM of 2-hydroxypyridine N-oxide
Escherichia coli
34
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM
Escherichia coli
35
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM and a concentration 20 mM of tetramethylenesulfoxide
Escherichia coli
36
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM and a concentration 20 mM of picolinic acid N-oxide or a concentration 20 mM of dimethylsulfoxide
Escherichia coli
105
-
purified enzyme, with trimethylamine N-oxide as substrate
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-chloropyridine N-oxide + electron donor
-
392773
Escherichia coli
2-chloropyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
3-hydroxypyridine N-oxide + electron donor
-
392773
Escherichia coli
3-hydroxypyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
3-picoline N-oxide + electron donor
-
392773
Escherichia coli
3-picoline + oxidized electron donor + H2O
-
392773
Escherichia coli
?
4-chloropyridine N-oxide + electron donor
-
392773
Escherichia coli
4-chloropyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
4-methylmorpholine N-oxide + electron donor
good substrate
392773
Escherichia coli
4-methylmorpholine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
alpha-picoline N-oxide + electron donor
-
392773
Escherichia coli
alpha-picoline + H2O + oxidized electron donor
-
392773
Escherichia coli
?
gamma-picoline N-oxide + electron donor
-
392773
Escherichia coli
gamma-picoline + H2O + oxidized electron donor
-
392773
Escherichia coli
?
hydroxylamine N-oxide + electron donor
-
392773
Escherichia coli
hydroxylamine + H2O + oxidized electron donor
-
392773
Escherichia coli
?
N,N-dimethyldodecylamine N-oxide + electron donor
-
392773
Escherichia coli
N,N-dimethyldodecylamine + H2O + oxidized electron donor
-
392773
Escherichia coli
?
N,N-dimethylhexylamine N-oxide + electron donor
-
392773
Escherichia coli
N,N-dimethylhexylamine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
N-cyclohexyldimethylamine N-oxide + electron donor
-
392773
Escherichia coli
N-cyclohexyldimethylamine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
pyridine N-oxide + electron donor
-
392773
Escherichia coli
pyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
trimethylamine N-oxide + electron donor
benzyl viologen as electron donor
392773
Escherichia coli
trimethylamine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
13.8
-
N,N-dimethylhexylamine N-oxide
-
Escherichia coli
45.6
-
N-cyclohexyldimethylamine N-oxide
-
Escherichia coli
49.2
-
3-hydroxypyridine N-oxide
-
Escherichia coli
49.6
-
gamma-picoline N-oxide
-
Escherichia coli
53.5
-
Pyridine N-oxide
-
Escherichia coli
66.7
-
4-chloropyridine N-oxide
-
Escherichia coli
70
-
hydroxylamine N-oxide
-
Escherichia coli
96.5
-
4-methylmorpholine N-oxide
-
Escherichia coli
101
-
2-chloropyridine N-oxide
-
Escherichia coli
102
-
alpha-picoline N-oxide
-
Escherichia coli
137
-
3-picoline N-oxide
-
Escherichia coli
151
-
Trimethylamine N-oxide
-
Escherichia coli
155
-
N,N-dimethyldodecylamine N-oxide
-
Escherichia coli
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.02
-
4-methylmorpholine N-oxide
-
Escherichia coli
0.07
-
Trimethylamine N-oxide
-
Escherichia coli
0.26
-
alpha-picoline N-oxide
-
Escherichia coli
0.32
-
gamma-picoline N-oxide
-
Escherichia coli
0.75
-
3-hydroxypyridine N-oxide
-
Escherichia coli
1.14
-
N,N-dimethylhexylamine N-oxide
-
Escherichia coli
1.25
-
N,N-dimethyldodecylamine N-oxide
-
Escherichia coli
1.86
-
Pyridine N-oxide
-
Escherichia coli
2.01
-
2-chloropyridine N-oxide
-
Escherichia coli
2.15
-
4-chloropyridine N-oxide
-
Escherichia coli
4.74
-
N-cyclohexyldimethylamine N-oxide
-
Escherichia coli
5.43
-
3-picoline N-oxide
-
Escherichia coli
7.39
-
hydroxylamine N-oxide
-
Escherichia coli
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
33
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM and a concentration 20 mM of 2-hydroxypyridine N-oxide
Escherichia coli
34
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM
Escherichia coli
35
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM and a concentration 20 mM of tetramethylenesulfoxide
Escherichia coli
36
-
purified enzyme, assay performed in 100 mM phosphate buffer, pH 6.8 with a trimethylamine N-oxide concentration 0.5 mM and a concentration 20 mM of picolinic acid N-oxide or a concentration 20 mM of dimethylsulfoxide
Escherichia coli
105
-
purified enzyme, with trimethylamine N-oxide as substrate
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-chloropyridine N-oxide + electron donor
-
392773
Escherichia coli
2-chloropyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
3-hydroxypyridine N-oxide + electron donor
-
392773
Escherichia coli
3-hydroxypyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
3-picoline N-oxide + electron donor
-
392773
Escherichia coli
3-picoline + oxidized electron donor + H2O
-
392773
Escherichia coli
?
4-chloropyridine N-oxide + electron donor
-
392773
Escherichia coli
4-chloropyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
4-methylmorpholine N-oxide + electron donor
good substrate
392773
Escherichia coli
4-methylmorpholine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
alpha-picoline N-oxide + electron donor
-
392773
Escherichia coli
alpha-picoline + H2O + oxidized electron donor
-
392773
Escherichia coli
?
gamma-picoline N-oxide + electron donor
-
392773
Escherichia coli
gamma-picoline + H2O + oxidized electron donor
-
392773
Escherichia coli
?
hydroxylamine N-oxide + electron donor
-
392773
Escherichia coli
hydroxylamine + H2O + oxidized electron donor
-
392773
Escherichia coli
?
N,N-dimethyldodecylamine N-oxide + electron donor
-
392773
Escherichia coli
N,N-dimethyldodecylamine + H2O + oxidized electron donor
-
392773
Escherichia coli
?
N,N-dimethylhexylamine N-oxide + electron donor
-
392773
Escherichia coli
N,N-dimethylhexylamine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
N-cyclohexyldimethylamine N-oxide + electron donor
-
392773
Escherichia coli
N-cyclohexyldimethylamine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
pyridine N-oxide + electron donor
-
392773
Escherichia coli
pyridine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
trimethylamine N-oxide + electron donor
benzyl viologen as electron donor
392773
Escherichia coli
trimethylamine + oxidized electron donor + H2O
-
392773
Escherichia coli
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
13.8
-
N,N-dimethylhexylamine N-oxide
-
Escherichia coli
45.6
-
N-cyclohexyldimethylamine N-oxide
-
Escherichia coli
49.2
-
3-hydroxypyridine N-oxide
-
Escherichia coli
49.6
-
gamma-picoline N-oxide
-
Escherichia coli
53.5
-
Pyridine N-oxide
-
Escherichia coli
66.7
-
4-chloropyridine N-oxide
-
Escherichia coli
70
-
hydroxylamine N-oxide
-
Escherichia coli
96.5
-
4-methylmorpholine N-oxide
-
Escherichia coli
101
-
2-chloropyridine N-oxide
-
Escherichia coli
102
-
alpha-picoline N-oxide
-
Escherichia coli
137
-
3-picoline N-oxide
-
Escherichia coli
151
-
Trimethylamine N-oxide
-
Escherichia coli
155
-
N,N-dimethyldodecylamine N-oxide
-
Escherichia coli
Other publictions for EC 1.7.2.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743776
Lemaire
Efficient respiration on TMAO ...
Shewanella oneidensis
Res. Microbiol.
167
630-637
2016
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687081
Zhang
Structure of the molybdenum si ...
Escherichia coli
Inorg. Chem.
47
1074-1078
2008
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1
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1
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687424
Dunn
Genetic analysis of trimethyla ...
Aliivibrio fischeri, Aliivibrio fischeri ES114, Euprymna scolopes
J. Bacteriol.
190
5814-5823
2008
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2
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3
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1
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15
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1
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700261
Ansaldi
Aerobic TMAO respiration in Es ...
Escherichia coli
Mol. Microbiol.
66
484-494
2007
1
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1
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1
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3
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2
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671735
Genest
Signal peptide protection by s ...
Escherichia coli
Biochem. Biophys. Res. Commun.
339
991-995
2006
1
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1
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1
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654560
Hatzixanthis
Chaperones involved in assembl ...
Escherichia coli, Shewanella massilia
Biochem. Soc. Trans.
33
124-126
2005
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2
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2
1
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1
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3
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1
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1
3
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1
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1
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2
1
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1
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1
3
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656279
Genest
TorD, an essential chaperone f ...
Escherichia coli
J. Biol. Chem.
280
15644-15648
2005
1
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1
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3
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676796
Hatzixanthis
Signal peptide-chaperone inter ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
102
8460-8465
2005
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1
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655851
Bordi
Effects of ISSo2 insertions in ...
Shewanella oneidensis
J. Bacteriol.
185
2042-2045
2003
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656147
Ilbert
Involvement of a mate chaperon ...
Escherichia coli
J. Biol. Chem.
278
28787-28792
2003
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1
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1
1
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4
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1
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1
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1
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392780
Gon
Reconstitution of the trimethy ...
Shewanella oneidensis
J. Bacteriol.
184
1262-1269
2002
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1
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6
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657290
Tranier
Characterization and multiple ...
Shewanella massilia
Protein Sci.
11
2148-2157
2002
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1
1
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1
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8
1
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1
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1
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1
3
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1
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1
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8
1
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3
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437732
Gon
Electron transfer and binding ...
Escherichia coli
J. Biol. Chem.
276
11545-11551
2001
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437733
Gon
An unsuspected autoregulatory ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
98
11615-11620
2001
-
-
1
-
-
-
-
-
1
-
-
-
-
2
-
-
1
-
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-
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-
-
-
-
-
-
-
-
-
-
437734
Gon
The torYZ (yecK bisZ) operon e ...
Escherichia coli
J. Bacteriol.
182
5779-5786
2000
-
-
1
-
-
-
-
4
1
-
-
-
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
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-
1
1
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-
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4
1
-
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1
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-
-
-
4
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
392776
Buc
Enzymatic and physiological pr ...
Escherichia coli
Mol. Microbiol.
32
159-168
1999
-
-
-
-
-
1
-
16
-
1
-
-
-
2
-
-
-
-
-
-
1
-
10
-
2
-
1
16
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
16
-
1
-
-
-
-
-
-
-
-
1
-
10
-
2
-
1
16
2
-
-
-
-
-
-
-
-
-
392777
Ansaldi
TorC apocytochrome negatively ...
Escherichia coli
Mol. Microbiol.
33
284-295
1999
-
-
1
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
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-
-
-
-
-
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-
-
1
-
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-
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1
1
-
-
-
-
1
-
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-
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-
-
-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392778
Mikhaleva
Requirement for phospholipids ...
Escherichia coli
FEBS Lett.
463
331-335
1999
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
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-
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1
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392771
Czjzek
Crystal structure of oxidized ...
Shewanella massilia, Shewanella massilia MR1
J. Mol. Biol.
284
435-447
1998
-
-
1
1
-
-
-
-
-
1
-
1
-
8
-
-
1
-
-
-
-
-
1
-
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-
-
-
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-
-
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1
-
1
-
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1
-
1
-
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-
1
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392774
Pommier
TorD, a cytoplasmic chaperone ...
Escherichia coli
J. Biol. Chem.
273
16615-16620
1998
-
-
-
-
-
-
-
-
2
1
-
-
-
3
-
-
1
-
-
-
5
-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
1
-
-
5
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392775
Dos Santos
Molecular analysis of the trim ...
Shewanella massilia
J. Mol. Biol.
284
421-433
1998
-
-
1
-
-
-
-
4
1
1
1
1
-
9
-
-
1
-
-
-
1
-
8
1
-
-
-
8
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
1
1
1
1
-
-
-
1
-
-
1
-
8
1
-
-
-
8
-
-
-
-
-
-
-
-
-
-
437735
Knäblein
Isolation, cloning, sequence a ...
Rhodobacter capsulatus
Biol. Chem.
378
293-302
1997
-
-
1
1
-
-
-
-
-
1
1
1
-
1
-
-
1
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
1
1
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392773
Iobbi-Nivol
High substrate specificity and ...
Escherichia coli
Biochim. Biophys. Acta
1294
77-82
1996
-
-
-
-
-
-
-
13
-
-
-
-
-
2
-
-
-
-
-
-
5
-
13
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
5
-
13
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
437737
Mejean
TMAO anaerobic respiration in ...
Escherichia coli
Mol. Microbiol.
11
1169-1179
1994
-
-
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
392772
Sajitz
-
Isolation and properties of tr ...
Rhodospirillum rubrum
Z. Naturforsch. C
48
812-814
1993
-
-
-
-
-
-
-
2
1
1
4
-
-
1
-
-
1
-
-
-
2
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
1
4
-
-
-
-
1
-
-
2
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437730
Arata
Purification and properties of ...
Roseobacter denitrificans
J. Biochem.
112
470-475
1992
-
-
-
-
-
1
-
1
-
1
2
-
-
4
-
-
1
-
-
-
1
1
5
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
2
-
-
-
-
1
-
-
1
1
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392761
Yamamoto
-
Anaerobic induction of trimeth ...
Escherichia coli
Curr. Microbiol.
20
245-249
1990
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392762
Silvestro
The inducible trimethylamine N ...
Escherichia coli
Biochim. Biophys. Acta
999
208-216
1989
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
392763
McEwan
-
Identification of cytochromes ...
Rhodobacter capsulatus
Biochim. Biophys. Acta
973
308-314
1989
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
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-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392758
Clarke
-
Purification and properties of ...
Shewanella sp.
J. Gen. Microbiol.
13
379-386
1988
-
-
-
-
-
-
9
3
1
1
2
-
-
1
-
-
1
-
-
-
1
-
8
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
9
-
3
1
1
2
-
-
-
-
1
-
-
1
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392764
Arata
Trimethylamine N-oxide respira ...
Erythrobacter sp., Erythrobacter sp. Och 114
J. Biochem.
103
1011-1015
1988
-
-
-
-
-
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392765
Silvestro
The inducible trimethylamine-N ...
Escherichia coli
Biochim. Biophys. Acta
954
1-13
1988
-
-
-
-
-
-
6
-
-
1
2
-
-
3
-
-
1
-
-
-
2
1
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
1
2
-
-
-
-
1
-
-
2
1
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392766
McEwan
-
The periplasmic nitrate reduct ...
Rhodobacter capsulatus
Biochem. Soc. Trans.
16
182-183
1988
-
-
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
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3
-
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-
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1
-
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1
-
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-
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-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392757
Yamamoto
Further characterization of tr ...
Escherichia coli
J. Biochem.
99
1773-1779
1986
-
-
-
-
-
-
4
4
-
3
2
-
-
3
-
-
1
-
-
-
1
-
5
1
-
-
2
-
2
-
-
2
-
-
-
-
-
-
2
-
-
-
-
4
-
4
-
3
2
-
-
-
-
1
-
-
1
-
5
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
392756
Violet
-
Trimethylamine N-oxide (TMAO) ...
Escherichia coli
FEMS Microbiol. Lett.
27
85-91
1985
-
-
-
-
-
-
4
-
2
-
-
-
-
1
1
-
-
-
-
-
-
1
2
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
-
2
-
-
-
-
1
-
-
-
-
-
1
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
392767
Styrvold
Dimethylsulfoxide and trimethy ...
Proteus vulgaris
Arch. Microbiol.
140
74-78
1984
-
-
-
-
-
-
-
2
-
-
1
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392755
Kwan
Purification and properties of ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Bacteriol.
155
1455-1458
1983
-
-
-
-
-
-
9
2
-
-
2
-
-
3
-
-
1
-
-
-
1
2
6
1
1
-
3
-
1
-
2
1
-
-
-
-
-
-
1
-
-
-
-
9
-
2
-
-
2
-
-
-
-
1
-
-
1
2
6
1
1
-
3
-
1
-
2
-
-
-
-
-
-
-
392768
Easter
-
The induction and location of ...
Alteromonas sp.
J. Gen. Microbiol.
129
3689-3696
1983
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
6
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
6
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392769
Bragg
Cytochromes of the trimethylam ...
Escherichia coli
Biochim. Biophys. Acta
725
168-177
1983
-
-
-
-
-
-
-
-
1
-
-
2
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
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1
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392770
Kwan
Roles for menaquinone and the ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Bacteriol.
155
1147-1155
1983
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
12
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392759
Cox
-
Trimethylamine N-oxide (TMAO) ...
Escherichia coli
FEMS Microbiol. Lett.
12
249-252
1981
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
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-
-
-
-
-
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-
1
-
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2
-
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