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Literature summary for 1.7.2.2 extracted from
- Cardiolipin modulates allosterically the nitrite reductase activity of horse heart cytochrome c (2014), J. Biol. Inorg. Chem., 19, 1195-1201 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cardiolipin | cardiolipin liposomes induce nitrite reductase activity of Fe(II)-cytc. The values observed can be compared with the kinetics of the NO2-mediated conversion of other ferrous heme-proteins. Cardiolipins facilitate the NO2-mediated nitrosylation of cytc-Fe(II) in a dose-dependent manner inducing the penta-coordination of the heme-Fe(II) atom | Equus caballus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Equus caballus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Equus caballus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Equus caballus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the NO2--mediated conversion of cardiolipin-cytc-Fe(II) to cardiolipin-cytc-Fe(II)-NO may play anti-apoptotic effects impairing lipid peroxidation and therefore the initiation of the cell death program by the release of pro-apoptotic factors in the cytoplasm | Equus caballus |
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