BRENDA - Enzyme Database show
show all sequences of 1.7.1.9

Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice

Benson, A.M.; Biochem. Pharmacol. 46, 1217-1221 (1993)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
not inhibited by dicoumarol
Mus musculus
additional information
not inhibited by 0.015 mM dicoumarol
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Rattus norvegicus
5829
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
partially
Mus musculus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitroquinoline N-oxide + NAD(P)H + H+
NADH is preferred, 15% activity with NADPH
392949
Rattus norvegicus
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
392949
Rattus norvegicus
?
4-nitroquinoline N-oxide + NAD(P)H + H+
strong preference for NADH
392949
Mus musculus
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
392949
Mus musculus
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
not inhibited by dicoumarol
Mus musculus
additional information
not inhibited by 0.015 mM dicoumarol
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Rattus norvegicus
5829
-
Purification (Commentary) (protein specific)
Commentary
Organism
partially
Mus musculus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitroquinoline N-oxide + NAD(P)H + H+
NADH is preferred, 15% activity with NADPH
392949
Rattus norvegicus
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
392949
Rattus norvegicus
?
4-nitroquinoline N-oxide + NAD(P)H + H+
strong preference for NADH
392949
Mus musculus
4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
-
392949
Mus musculus
?
Other publictions for EC 1.7.1.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
392949
Benson
Conversion of 4-nitroquinoline ...
Mus musculus, Rattus norvegicus
Biochem. Pharmacol.
46
1217-1221
1993
-
-
-
-
-
-
2
-
1
-
-
-
-
5
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
-
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-
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-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392948
Stanley
Nitroreductases and glutathion ...
Mus musculus
Cancer Res.
52
58-63
1992
-
-
-
-
-
-
1
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
1
-
1
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-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392946
Booth
A relationship found between i ...
Rattus norvegicus
Cell Tissue Kinet.
23
331-340
1990
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
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-
-
-
-
-
-
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-
-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392945
Suzuki
Distribution of 4-nitroquinoli ...
Canis lupus familiaris
Gann
69
229-235
1978
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
1
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392947
Suzuki
-
The distribution of 4-nitroqui ...
Cavia porcellus, Cricetinae, Felis catus, Oryctolagus cuniculus, Rattus norvegicus
Nihon Univ. J. Med.
20
345-357
1978
-
-
-
-
-
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-
-
-
-
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-
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5
-
-
-
-
-
-
9
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
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9
-
5
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