Literature summary for 1.7.1.6 extracted from

Fujita, S.; Peisach, J.
The stimulation of microsomal azoreduction by flavins (1982), Biochim. Biophys. Acta, 719, 178-189.

Search for more literature for 1.7.1.6

Activating Compound

Activating Compound	Comment	Organism	Structure
FMN	increases activity	Rattus norvegicus
methylviologen	activation	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
CO	noncompetitive vs. amaranth	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00645	-	CO	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	i.e. microsomes	Rattus norvegicus	5783	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid + NADPH	trivial name amaranth, activity in liver microsomes	Rattus norvegicus	alpha-naphthylamine-4-sulfonic acid + beta-naphthol-3,6-disulfonic acid + NADP+	-	?
4-(dimethylamino)azobenzene + 2 NADPH	-	Rattus norvegicus	N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ + 2 H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
FAD	increases activity	Rattus norvegicus
NADPH	-	Rattus norvegicus
riboflavin	activation	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.006	-	CO	-	Rattus norvegicus

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Release 2023.1 (January 2023)