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Literature summary for 1.7.1.10 extracted from

  • King, R.S.; Teitel, C.H.; Shaddock, J.G.; Casciano, D.A.; Kadlubar, F.F.
    Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the N-hydroxy derivative (1999), Cancer Lett., 143, 167-171.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-hydroxy-arylamines + NADH Homo sapiens enzyme may be involved in detoxification pathway of carcinogenic aromatic and heterocyclic amines N-arylamines + NAD+ + H2O
-
?
N-hydroxy-arylamines + NADH Rattus norvegicus enzyme may be involved in detoxification pathway of carcinogenic aromatic and heterocyclic amines N-arylamines + NAD+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
HepG2 cells
-
Rattus norvegicus
-
primary hepatocytes
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-hydroxy-1-naphthylamine + NADH
-
Homo sapiens 1-naphthylamine + NAD+ + H2O
-
?
N-hydroxy-1-naphthylamine + NADH activity in liver microsomes Rattus norvegicus 1-naphthylamine + NAD+ + H2O
-
?
N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine + NADH
-
Homo sapiens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine + NAD+ + H2O
-
?
N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine + NADH activity in liver microsomes, primary rat hepatocytes and human HepG2 cells Rattus norvegicus 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine + NAD+ + H2O
-
?
N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline + NADH
-
Homo sapiens 2-amino-3-methylimidazo[4,5-f]quinoxaline + NAD+ + H2O
-
?
N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline + NADH activity in liver microsomes Rattus norvegicus 2-amino-3-methylimidazo[4,5-f]quinoxaline + NAD+ + H2O
-
?
N-hydroxy-2-amino-alpha-carboline + NADH
-
Homo sapiens 2-amino-alpha-carboline + NAD+ + H2O
-
?
N-hydroxy-2-amino-alpha-carboline + NADH activity in liver microsomes Rattus norvegicus 2-amino-alpha-carboline + NAD+ + H2O
-
?
N-hydroxy-2-aminofluorene + NADH
-
Homo sapiens 2-aminofluorene + NAD+ + H2O
-
?
N-hydroxy-2-aminofluorene + NADH activity in liver microsomes Rattus norvegicus 2-aminofluorene + NAD+ + H2O
-
?
N-hydroxy-2-naphthylamine + NADH
-
Homo sapiens 2-naphthylamine + NAD+ + H2O
-
?
N-hydroxy-2-naphthylamine + NADH activity in liver microsomes Rattus norvegicus 2-naphthylamine + NAD+ + H2O
-
?
N-hydroxy-4,4'-methylenebis(2-chloroaniline) + NADH
-
Homo sapiens 4,4'-methylenebis(2-chloroaniline) + NAD+
-
?
N-hydroxy-4,4'-methylenebis(2-chloroaniline) + NADH activity in liver microsomes Rattus norvegicus 4,4'-methylenebis(2-chloroaniline) + NAD+
-
?
N-hydroxy-4-aminoazobenzene + NADH
-
Homo sapiens 4-aminoazobenzene + NAD+ + H2O
-
?
N-hydroxy-4-aminoazobenzene + NADH activity in liver microsomes Rattus norvegicus 4-aminoazobenzene + NAD+ + H2O
-
?
N-hydroxy-4-aminobiphenyl + NADH
-
Homo sapiens 4-aminobiphenyl + NAD+ + H2O
-
?
N-hydroxy-4-aminobiphenyl + NADH activity in liver microsomes Rattus norvegicus 4-aminobiphenyl + NAD+ + H2O
-
?
N-hydroxy-aniline + NADH
-
Homo sapiens aniline + NAD+ + H2O
-
?
N-hydroxy-aniline + NADH activity in liver microsomes Rattus norvegicus aniline + NAD+ + H2O
-
?
N-hydroxy-arylamines + NADH enzyme may be involved in detoxification pathway of carcinogenic aromatic and heterocyclic amines Homo sapiens N-arylamines + NAD+ + H2O
-
?
N-hydroxy-arylamines + NADH enzyme may be involved in detoxification pathway of carcinogenic aromatic and heterocyclic amines Rattus norvegicus N-arylamines + NAD+ + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADH
-
Rattus norvegicus