Literature summary for 1.6.5.9 extracted from

Gospodaryov, D.V.; Strilbytska, O.M.; Semaniuk, U.V.; Perkhulyn, N.V.; Rovenko, B.M.; Yurkevych, I.S.; Barata, A.G.; Dick, T.P.; Lushchak, O.V.; Jacobs, H.T.
Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila (2020), Biogerontology, 21, 155-171 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Ciona intestinalis	5739	-

Organism

Organism	UniProt	Comment	Textmining
Ciona intestinalis	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
NDX	-	Ciona intestinalis

General Information

General Information	Comment	Organism
physiological function	Drosophila melanogaster expressing alternative NADH dehydrogenase NDX have 17-71% lifespan prolongation on media with different protein-to-carbohydrate ratios except NDX-expressing males that have 19% shorter lifespan than controls on a high protein diet. NDX-expressing flies are more resistant to 2,4-dichlorophenoxyacetic acid and alloxan, and to potassium iodate, and partially to sodium molybdate treatments. NDX-expressing flies are more sensitive to catechol and sodium chromate	Ciona intestinalis

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Release 2023.1 (January 2023)