Literature summary for 1.6.5.9 extracted from

Bahadorani, S.; Cho, J.; Lo, T.; Contreras, H.; Lawal, H.O.; Krantz, D.E.; Bradley, T.J.; Walker, D.W.
Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan (2010), Aging Cell, 9, 191-202.

Cloned(Commentary)

Cloned (Comment)	Organism
gene Ndi1, inducible NDI1 enzyme expression in Drosophila melanogaster mitochondria of different cells and tissues. Expression of Ndi1 in fly mitochondria leads to an increase in NADH-ubiquinone oxidoreductase activity, oxygen consumption and ATP levels. In addition, exogenous Ndi1 expression results in increased CO2 production in living flies. Targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity	Saccharomyces cerevisiae

Cloned (Comment)

Organism

gene Ndi1, inducible NDI1 enzyme expression in Drosophila melanogaster mitochondria of different cells and tissues. Expression of Ndi1 in fly mitochondria leads to an increase in NADH-ubiquinone oxidoreductase activity, oxygen consumption and ATP levels. In addition, exogenous Ndi1 expression results in increased CO2 production in living flies. Targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity

Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Ndi1 is rotenone-insensitive	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	gene Ndi1	-

Synonyms

Synonyms	Comment	Organism
NADH-ubiquinone oxidoreductase	-	Saccharomyces cerevisiae
Ndi1	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
additional information	targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity. Expression of the yeast Ndi1 gene in Drosophila mitochondria leads to an increase in respiratory chain activity, overview	Saccharomyces cerevisiae
physiological function	NDI1 cannot promote proton pumping	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)