Literature summary for 1.6.5.5 extracted from

Shukla, V.; Asthana, S.; Yadav, S.; Rajput, V.S.; Tripathi, A.
Emodin inhibited NADPH-quinone reductase competitively and induced cytotoxicity in rat primary hepatocytes (2020), Toxicon, 188, 117-121 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
emodin	i.e. an anthraquinone, inhibits the enzymatic activity of NADPH-quinone reductase by binding to the active site. Emodin acts as a competitive inhibitor with respect to 2, 6-dichlorophenolindophenol, and emodin shows cytotoxicity against rat hepatocytes	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0118	-	NADPH	pH not specified in the publication, temperature not specified in the publication	Rattus norvegicus
0.039	-	dichlorophenolindophenol	pH not specified in the publication, temperature not specified in the publication	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary hepatocyte	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dichlorophenolindophenol + NADPH + H+	-	Rattus norvegicus	reduced dichlorophenolindophenol + NADP+	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.061	-	pH not specified in the publication, temperature not specified in the publication	Rattus norvegicus	emodin

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Release 2023.1 (January 2023)