Literature summary for 1.6.5.2 extracted from

Gray, J.P.; Karandrea, S.; Burgos, D.Z.; Jaiswal, A.A.; Heart, E.A.
NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) and cytochrome P450 oxidoreductase (CYP450OR) differentially regulate menadione-mediated alterations in redox status, survival and metabolism in pancreatic beta-cells (2016), Toxicol. Lett., 262, 1-11 .

Search for more literature for 1.6.5.2

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P05982	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Rattus norvegicus	-
pancreatic islet	-	Rattus norvegicus	-

Cofactor

Cofactor	Comment	Organism	Structure
NADH	in pancreatic beta-cells, NQR1 primarily utilizes NADH	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	basal expression of NQO1 and NADPH cytochrome P450 oxidoreductase is comparable in isolated islets and liver	additional information
Rattus norvegicus	NQO1, but not NADPH cytochrome P450 oxidoreductase , is strongly induced in pancreatic beta-cells exposed to menadione	up

General Information

General Information	Comment	Organism
physiological function	in addition to protection of b-cells from toxic concentrations of the redox cycling quinone menadione, NQO1 also regulates the basal level of reduced-to-oxidized nucleotides	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)