Literature summary for 1.6.5.2 extracted from

Philbrook, N.A.; Winn, L.M.
Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase potential implications for fetal protection aga (2014), Reprod. Toxicol., 43, 30-37 .

Search for more literature for 1.6.5.2

Application

Application	Comment	Organism
medicine	in sub-chronic studies upon oral exposure to sulphoraphane for 30 days a 2- to 3fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2fold increase in NQO1 activity in adult livers is observed	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q64669	-	-

Expression

Organism	Comment	Expression
Mus musculus	upon acute treatment with sulforaphane, increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels are observed in adult liver, but no change in NQO1 activity	additional information
Mus musculus	in sub-chronic studies upon oral exposure to sulphoraphane for 30 days a 2- to 3fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2fold increase in NQO1 activity in adult livers is observed	up

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)