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Literature summary for 1.6.5.2 extracted from

  • Zhang, X.; Han, K.; Yuan, D.H.; Meng, C.Y.
    Overexpression of NAD(P)H quinone oxidoreductase 1 inhibits hepatocellular carcinoma cell proliferation and induced apoptosis by activating AMPK/PGC-1alpha pathway (2017), DNA Cell Biol., 36, 256-263 .
    View publication on PubMed

Application

Application Comment Organism
medicine NQO1 overexpression induces hepatocellular carcinoma cell apoptosis and proliferation inhibition through the AMPK/PGC-1a pathway Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15559
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-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
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Homo sapiens
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SK-HEP-1 cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
NQO1
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Homo sapiens

General Information

General Information Comment Organism
physiological function NQO1 overexpression inhibits apoptosis-associated gene Bcl-2 expression and promotes apoptosis-associated gene Bax and caspase-3 expression, whereas NQO1 silencing plays a contrasting role. NQO1 activates AMP-activated protein kinase AMPK and proliferator-activated receptor gamma coactivator PGC-1a, and the AMPK inhibitor compound C blocks NQO1-induced PGC-1a activationand partially abolishes NQO1-induced cell apoptosis and proliferation inhibition in hepatocellular carcinoma cells Homo sapiens