Application | Comment | Organism |
---|---|---|
medicine | NQO1 overexpression induces hepatocellular carcinoma cell apoptosis and proliferation inhibition through the AMPK/PGC-1a pathway | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15559 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | - |
Homo sapiens | - |
SK-HEP-1 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
NQO1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | NQO1 overexpression inhibits apoptosis-associated gene Bcl-2 expression and promotes apoptosis-associated gene Bax and caspase-3 expression, whereas NQO1 silencing plays a contrasting role. NQO1 activates AMP-activated protein kinase AMPK and proliferator-activated receptor gamma coactivator PGC-1a, and the AMPK inhibitor compound C blocks NQO1-induced PGC-1a activationand partially abolishes NQO1-induced cell apoptosis and proliferation inhibition in hepatocellular carcinoma cells | Homo sapiens |