Literature summary for 1.6.5.2 extracted from

Shrestha, A.K.; Patel, A.; Menon, R.T.; Jiang, W.; Wang, L.; Moorthy, B.; Shivanna, B.
Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice (2017), Biochem. Biophys. Res. Commun., 485, 195-200 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q64669	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	leflunomide elicites significant induction of pulmonary CYP1A1 and NQO1 expression in neonatal mice	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
NQO1	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	leflunomide elicits significant induction of pulmonary CYP1A1 and NQO1 expression in neonatal mice. The dose at which leflunomide increases NQO1 is significantly higher than that required to induce CYP1A1 enzyme. Leflunomide also enhances hepatic CYP1A1, 1A2 and NQO1 expression in wild-type mice and fails to induce these enzymes in aryl hydrocarbon receptor-null mice	up

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Release 2023.1 (January 2023)