Any feedback?
Literature summary for 1.6.5.2 extracted from
- The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity (2008), Toxicology, 247, 11-22.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3-nitrobenzanthrone | increases protein level and enzymatic activity of NQO1. Up to a 2.5fold increase in NQO1 activity with menadione as substrate in tissues of rats treated with 3-nitrobenzanthrone | Rattus norvegicus |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | 3-nitrobenzanthrone is capable to induce NQO1 and CYP1A1 in lungs and kidney of rats thereby enhancing its own genotoxic and carcinogenic potential | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dicoumarol | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.05 | - |
in lung of control rats | Rattus norvegicus |
| 0.06 | - |
in lung of rats treated with 0.4 or 4 mg/kg of 3-nitrobenzanthrone | Rattus norvegicus |
| 0.09 | - |
in kidney of control rats and in lung of rats treated with 40 mg/kg of 3-nitrobenzanthrone | Rattus norvegicus |
| 0.15 | - |
in kidney of rats treated with 0.4 or 4 mg/kg of 3-nitrobenzanthrone | Rattus norvegicus |
| 0.23 | - |
in kidney of rats treated with 40 mg/kg of 3-nitrobenzanthrone | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| menadione + NADPH | - |
Rattus norvegicus | reduced menadione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAD(P)H:quinone oxidoreductase | - |
Rattus norvegicus |
| NQO1 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
