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Literature summary for 1.6.5.2 extracted from

  • Choi, E.K.; Terai, K.; Ji, I.M.; Kook, Y.H.; Park, K.H.; Oh, E.T.; Griffin, R.J.; Lim, B.U.; Kim, J.S.; Lee, D.S.; Boothman, D.A.; Loren, M.; Song, C.W.; Park, H.J.
    Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells (2007), Neoplasia, 9, 634-642.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
additional information irradiation with 4 Gy causes a long-lasting upregulation of NQO1, thereby increasing NQO1-mediated beta-lap-induced cell deaths Homo sapiens

Application

Application Comment Organism
medicine NQO1-induced bioreduction of beta-lap is an essential step in beta-lap-induced cell death. Combined radiotherapy and beta-lap treatment can have a significant effect on human tumor xenografts Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol inhibitor of NQO1, inhibits clonogenic cell death caused by beta-lap Homo sapiens
siRNA siRNA for NQO1 inhibits clonogenic cell death caused by beta-lap Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
additional information lung epithelial cancer cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytochrome C + menadione + NADH
-
 Homo sapiens ? + reduced menadione + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
NAD(P)H:quinone oxidoreductase
-
 Homo sapiens
NQO1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens