Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Clofibrate | administration to animals for 5 to 10 days, increase in enzyme protein and activity | Mus musculus | |
Clofibrate | administration to animals for 5 to 10 days, increase in enzyme protein and activity | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | acetaminophen is bioactivated by cytochrome P450 to the reactive intermediate N-acetyl-p-benzoquinone imine. Enhanced levels of hepatic enzyme may detoxify N-acetyl-p-benzoquinone imine by reducing it back to acetaminophen | Homo sapiens |
medicine | clofibrate-mediated hepatoprotection against acetaminophen does not appear to be dependent upon enhanced expression of enzyme. Conditions of 94% inhobition of enzyme do not increase the susceptibility of hepatocytes from clofibrate treated mice to acetaminophen | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant isoform NQO1 | - |
Mus musculus | - |
- |
- |
Mus musculus CD-1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaminophen + NAD(P)H + H+ | - |
Homo sapiens | N-acetyl-p-benzoquinone imine + NAD(P)+ | enhanced levels of hepatic enzyme may detoxify N-acetyl-p-benzoquinone imine by reducing it back to acetaminophen | r |