Literature summary for 1.6.5.2 extracted from

van Horssen, J.; Schreibelt, G.; Bo, L.; Montagne, L.; Drukarch, B.; van Muiswinkel, F.L.; de Vries, H.E.
NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions (2006), Free Radic. Biol. Med., 41, 311-317.

Search for more literature for 1.6.5.2

Application

Application	Comment	Organism
medicine	enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	increased enzyme expression reflects an endogenous defense response against reactive oxygen species-mediated cellular toxicity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with multiple sclerosis	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages	Homo sapiens	-
macrophage	enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	increased enzyme expression reflects an endogenous defense response against reactive oxygen species-mediated cellular toxicity	Homo sapiens	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)