Activating Compound | Comment | Organism | Structure |
---|---|---|---|
eugenol | increases expression and activity of enzyme by NF-E2 related factor2 binding to antioxidant response element in enzyme gene | Homo sapiens | |
eugenol | increases the expression and activity of NAD(P)H:quinone oxidoreductase through NF-E2 related factor2 binding to antioxidant response element in QR gene in a dose-dependent manner | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | NAD(P)H:quinone oxidoreductase is a major detoxifying enzyme for 7,12-dimethylbenz[a]anthracene. Eugenol has a potent protective effect against 7,12-dimethylbenz[a]anthracene-induced genotoxicity, presumably through the suppression of the 7,12-dimethylbenz[a]anthracene activation and the induction of its detoxification through NAD(P)H:quinone oxidoreductase | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
QR-ARE-luciferase reporter plasmid expressed in MCF-7 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
menadione + NADH | - |
Homo sapiens | reduced menadione + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H:quinone oxidoreductase | - |
Homo sapiens |