Literature summary for 1.6.5.2 extracted from

SantaCruz, K.S.; Yazlovitskaya, E.; Collins, J.; Johnson, J.; DeCarli, C.
Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease (2004), Neurobiol. Aging, 25, 63-69.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	NQO1 activity colocalizes closely with Alzheimers disease pathology supporting a presumed role as an antioxidant system upregulated in response to the oxidative stress of the Alzheimers disease process	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls, specific localization to astrocytes and neurites surrounding senile plaques. Neuronal NQO1 staining seen in frontal cortex of Alzheimers disease patients is absent in frontal cortex of controls, but is found to the same extent in neurons of the substantia nigra of both Alzheimers disease patients and controls	Homo sapiens	-
cerebellar cortex	the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls	Homo sapiens	-
cerebellum	the ratio of frontal to cerebellar NQO1 activity is significantly increased in patients with Alzheimers disease versus controls	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	NQO1 activity colocalizes closely with Alzheimers disease pathology supporting a presumed role as an antioxidant system upregulated in response to the oxidative stress of the Alzheimers disease process	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
NAD(P)H:quinone oxidoreductase	-	Homo sapiens
NQO1	-	Homo sapiens

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Release 2023.1 (January 2023)