Literature summary for 1.6.5.2 extracted from

Pink, J.J.; Planchon, S.M.; Tagliarino, C.; Varnes, M.E.; Siegel, D.; Boothman, D.A.
NAD(P)H:quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity (2000), J. Biol. Chem., 275, 5416-5424.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	breast cancer cell lines	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione + NAD(P)H	trivial name beta-lapachone, potent cytotoxic agent against various cancer cell lines	Homo sapiens	3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-diol + NAD(P)+	-	?

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Release 2023.1 (January 2023)