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Literature summary for 1.6.5.10 extracted from
- Role of nitric oxide in downregulation of cytochrome P450 1a1 and NADPH: Quinone oxidoreductase 1 by tumor necrosis factor-alpha and lipopolysaccharide (2007), J. Pharm. Sci., 96, 2795-2807.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| beta-naphthoflavone | - |
Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (N-methyl-4'-pyridyl) porphyrin | iron tetrakis, FeTMPyP, no inhibitory activity | Mus musculus | |
| L-N6-(1-iminoethyl) lysine | no inhibitory activity | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hepa-1c1c7 cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0005 | - |
medium alone | Mus musculus |
| 0.0007 | - |
TNFalpha and LPS inhibit the beta-naphthoflavone induced increase in activity | Mus musculus |
| 0.0012 | - |
in presence of beta-naphthoflavone | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + H+ + quinone | TNF alpha and LPS induce Nqo1 mRNA expression | Mus musculus | NADP+ + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NADPH:quinone oxidoreductase 1 | - |
Mus musculus |
| NQO1 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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