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Literature summary for 1.6.3.1 extracted from

  • Azouzi, N.; Cailloux, J.; Cazarin, J.M.; Knauf, J.A.; Cracchiolo, J.; Al Ghuzlan, A.; Hartl, D.; Polak, M.; Carre, A.; El Mzibri, M.; Filali-Maltouf, A.; Al Bouzidi, A.; Schlumberger, M.; Fagin, J.A.; Ameziane-El-Hassani, R.; Dupuy, C.
    NADPH oxidase NOX4 is a critical mediator of BRAF(V600E)-induced downregulation of the sodium/iodide symporter in papillary thyroid carcinomas (2017), Antioxid. Redox Signal., 26, 864-877 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Homo sapiens
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
8505C cell
-
 Homo sapiens
-
BCPAP cell
-
 Homo sapiens
-
papillary thyroid carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Homo sapiens NADP+ + H2O2
-
 ?

Subunits

Subunits Comment Organism
? x * 65000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
NADPH oxidase
-
 Homo sapiens
Nox4
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the BRAFV600E oncogene upregulates the enzyme NOX4 via TGF-beta1 signaling pathway in papillary thyroid cancer cell line up

General Information

General Information Comment Organism
physiological function NADPH oxidase NOX4 is a critical mediator of BRAF(V600E)-induced downregulation of the sodium/iodide symporter in papillary thyroid carcinomas Homo sapiens