Literature summary for 1.6.3.1 extracted from

Zhao, R.; Le, K.; Moghadasian, M.H.; Shen, G.X.
Regulatory role of NADPH oxidase in glycated LDL-induced upregulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts and diabetic mice (2013), Free Radic. Biol. Med., 61C, 18-25.

Search for more literature for 1.6.3.1

Inhibitors

Inhibitors	Comment	Organism	Structure
diphenyleneiodonium	a nonspecific NOX inhibitor	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus C57BL/6	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-
heart	the amount of NOX4 is elevated in hearts of db/db diabetic mice compared to wild-type mice	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
NOX	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	oxidized low-density lipoprotein increases the amounts of NADPH oxidase in fibroblasts. Treatment with physiologically relevant levels of glycated low-density lipoprotein increases superoxide and H2O2 release and the levels of NOX4 and p22phox, an essential component of multiple NOX complexes, in wild-type or HSF1-deficient mouse embryonic fibroblasts. Small interfering RNA for p22phox prevents the increase in expression of Nox4 in fibroblasts. The results suggest that glyLDL increases the abundance of NOX4 or p22phox via an HSF1-independent pathway, but that of PAI-1 via an HSF1-dependent manner	up

General Information

General Information	Comment	Organism
malfunction	specific inhibition of NOX by transfection of siRNA against p22phox mRNA effectively blocks low-density lipoprotein- or glycated low-density lipoprotein-induced increases in p22phox, NOX4, PAI-1, and HSF1 in wild-type mouse embryonic fibroblasts	Mus musculus
physiological function	regulatory role of NADPH oxidase in glycated low-density lipoprotein-induced upregulation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts and diabetic mice, overview. NOX4 plays a crucial role in glycated low-density lipoprotein-induced expression of HSF1andPAI-1 in mouse fibroblasts	Mus musculus

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Release 2023.1 (January 2023)