Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | also named acetovanillone, 4'-hydroxy-3'-methoxyacetophenone | Oryctolagus cuniculus | |
apocynin | also named acetovanillone, 4'-hydroxy-3'-methoxyacetophenone | Rattus norvegicus | |
additional information | mGluR5 activation inhibits microglial NADPH oxidase activity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Rattus norvegicus | - |
kidney | - |
Oryctolagus cuniculus | - |
microglial cell | - |
Rattus norvegicus | - |
renal proximal tubule | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | - |
Oryctolagus cuniculus | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | the active enzyme complex produces O2 radicals, which are converted into superoxide-derived oxidants such as H2O2, hydroxyl radicals, and peroxynitrite | Rattus norvegicus | NADP+ + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH oxidase | - |
Rattus norvegicus |
NADPH oxidase | - |
Oryctolagus cuniculus |
NOX | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Oryctolagus cuniculus |
General Information | Comment | Organism |
---|---|---|
malfunction | the inhibition of NADPH oxidase may contribute to lowered rate of renal gluconeogenesis, probably due to decreasing phosphoenolpyruvate carboxykinase activity | Rattus norvegicus |
malfunction | the inhibition of NADPH oxidase may contribute to lowered rate of renal gluconeogenesis, probably due to decreasing phosphoenolpyruvate carboxykinase activity | Oryctolagus cuniculus |