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Literature summary for 1.6.3.1 extracted from

  • Winiarska, K.; Grabowski, M.; Rogacki, M.K.
    Inhibition of renal gluconeogenesis contributes to hypoglycaemic action of NADPH oxidase inhibitor, apocynin (2011), Chem. Biol. Interact., 189, 119-126.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
apocynin also named acetovanillone, 4'-hydroxy-3'-methoxyacetophenone Oryctolagus cuniculus
apocynin also named acetovanillone, 4'-hydroxy-3'-methoxyacetophenone Rattus norvegicus
additional information mGluR5 activation inhibits microglial NADPH oxidase activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Rattus norvegicus
-
kidney
-
Oryctolagus cuniculus
-
microglial cell
-
Rattus norvegicus
-
renal proximal tubule
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
Oryctolagus cuniculus NADP+ + H2O2
-
?
NADPH + H+ + O2 the active enzyme complex produces O2 radicals, which are converted into superoxide-derived oxidants such as H2O2, hydroxyl radicals, and peroxynitrite Rattus norvegicus NADP+ + H2O2
-
?

Synonyms

Synonyms Comment Organism
NADPH oxidase
-
Rattus norvegicus
NADPH oxidase
-
Oryctolagus cuniculus
NOX
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Oryctolagus cuniculus

General Information

General Information Comment Organism
malfunction the inhibition of NADPH oxidase may contribute to lowered rate of renal gluconeogenesis, probably due to decreasing phosphoenolpyruvate carboxykinase activity Rattus norvegicus
malfunction the inhibition of NADPH oxidase may contribute to lowered rate of renal gluconeogenesis, probably due to decreasing phosphoenolpyruvate carboxykinase activity Oryctolagus cuniculus