Literature summary for 1.6.3.1 extracted from

Hwang, J.; Kleinhenz, D.J.; Rupnow, H.L.; Campbell, A.G.; Thule, P.M.; Sutliff, R.L.; Hart, C.M.
The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice (2007), Vascul. Pharmacol., 46, 456-462.

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Application

Application	Comment	Organism
medicine	in obese, diabetic, leptin-receptor deficient db-/db- mice, mRNA levels of enzyme subunits Nox-1, Nox-2, and Nox-4 as well as Nox-2 protein expression are elevated, whereas aortic Cu/Zn superoxide dismutase protein and PPARgamma mRNA levels are reduced	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	in obese, diabetic, leptin-receptor deficient db-/db- mice, mRNA levels of enzyme subunits Nox-1, Nox-2, and Nox-4 as well as Nox-2 protein expression are elevated, whereas aortic Cu/Zn superoxide dismutase protein and PPARgamma mRNA levels are reduced	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
rosiglitazone	treatment of animals for 1 week significantly reduces aortic superoxide production and the mRNA expression of enzyme subunits Nox-1, Nox-2, and Nox-4	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

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Release 2023.1 (January 2023)