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Literature summary for 1.6.3.1 extracted from

  • Park, K.W.; Jin, B.K.
    Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase (2008), J. Neurosci. Res., 86, 1053-1063.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thrombin after addition to cell culture, expression of NADPH oxidase subunits p47phox and p67phox occurs, accompanied by up-regulation in the expression of cytosolic enzyme components Rac 1 and p67phox, and the translocation of cytosolic subunits p47phox and p67phox to the membrane. Thrombin-induced reactive oxygen species production, protein oxidation, and loss of cultured hippocampal neurons are partially attenuated by NADPH oxidase inhibition and/or by several antioxidants Rattus norvegicus

Application

Application Comment Organism
medicine after addition of thrombin to cell culture, expression of NADPH oxidase subunits p47phox and p67phox occurs, accompanied by up-regulation in the expression of cytosolic enzyme components Rac 1 and p67phox, and the translocation of cytosolic subunits p47phox and p67phox to the membrane. Thrombin-induced reactive oxygen species production, protein oxidation, and loss of cultured hippocampal neurons are partially attenuated by NADPH oxidase inhibition and/or by several antioxidants Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
hippocampus neuron-enriched hippocampal culture Rattus norvegicus
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