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Literature summary for 1.6.3.1 extracted from
- HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities (2007), J. Invest. Dermatol., 127, 2001-2011.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| A23187 | calcium ionophore. HaCaT keratinocytes overexpressing calcium- and arachidonic acid binding proteins S100A8/S100A9 showed enhanced, transient reactive oxygen species generation in response to A23187, as well as nuclear factor kappaB activation and increase in interleukin-8 mRNA levels | Homo sapiens |  |
| phorbol 12-myristate 13-acetate | after transfection with calcium- and arachidonic acid binding proteins S100A8/S100A9 genes, HeLa cells show dramatically increased activation of NAD(P)H oxidase in presence of phorbol 12-myristate 13-acetate | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HaCaT cell | keratinocyte | Homo sapiens | - |
| HeLa cell | exclusive expression of isoform Nox2 | Homo sapiens | - |
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