Protein Variants | Comment | Organism |
---|---|---|
additional information | in cells deficient for von Hippel-Lindau tumor suppressor gene, protein levels of subunit p22phox, of isoform Nox4 and NADPH-dependent superoxide levels are increased. Down-regulation of isoforms Nox1, Nox4, and p22phox expression by small interfering RNA decreases hypoxia-inducible factor 2alpha# protein expression and inhibits Akt and 4E-BP1 phosphorylation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphenylene iodonium | inhibition of NADPH oxidase. In cells deficient for von Hippel-Lindau tumor suppressor gene, presence of diphenyleneiodonium decreases the expression of hypoxia-inducible factor 2alpha | Homo sapiens | |
diphenylene iodonium | significantly inhibits RCC 786-O tumor formation in athymic mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ACHN cell | - |
Homo sapiens | - |
HK-2 cell | - |
Homo sapiens | - |
RCC 786-O cell | deficient for von Hippel-Lindau tumor suppressor gene | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | subunit p22phox co-immunoprecipitates with Hippel-Lindau tumor suppressor in vivo and is target of ubiquitination | Homo sapiens |