Protein Variants | Comment | Organism |
---|---|---|
additional information | in mice lacking the subunit gp91phox, the effects of low K intake on superoxide production, c-Jun phosphorylation, c-Src expression, and tyrosine phosphorylation of ROMK channels are significantly attenuated | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | K+ depletion increases superoxide levels, phosphorylation of c-Jun, expression of c-Src, and tyrosine phosphorylation of ROMK channel in renal cortex and outer medulla in wild-type mice. Low K+ intake decreases mean product of channel number and open probability of ROMK channels. In mice lacking the NAD(P)H oxidase subunit gp91phox, the effects of low K intake are significantly attenuated | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | superoxide anions play a key role in suppressing K +secretion during K+ restriction and isoform NoxII is involved in mediating the effect of low K +intake on renal K+ secretion and ROMK channel activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform NoxII | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | superoxide anions play a key role in suppressing K +secretion during K+ restriction and isoform NoxII is involved in mediating the effect of low K +intake on renal K+ secretion and ROMK channel activity | Mus musculus | ? | - |
? |