Literature summary for 1.6.3.1 extracted from

Deng, S.; Kruger, A.; Kleschyov, A.L.; Kalinowski, L.; Daiber, A.; Wojnowski, L.
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH (2007), Free Radic. Biol. Med., 42, 466-473.

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Activating Compound

Activating Compound	Comment	Organism	Structure
doxorubicin	induction of superoxide production by doxorubicin is much higher in hearts of wild-type mice than in subunit gp91phox knock-out mice	Mus musculus
additional information	superoxide production is induced by addition of NADPH cytochrome P450 reductase	Mus musculus

Application

Application	Comment	Organism
medicine	induction of superoxide production by doxorubicin is much higher in hearts of wild-type mice than in subunit gp91phox knock-out mice. Superoxide production is similarly induced by addition of NADPH cytochrome P450 reductase	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	female wild-type and NAD(P)H oxidase deficient gp91phox knock-out mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	induction of superoxide production by doxorubicin is much higher in hearts of wild-type mice than in subunit gp91phox knock-out mice. Superoxide production is similarly induced by addition of NADPH cytochrome P450 reductase	Mus musculus	-

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Release 2023.1 (January 2023)